246 CYTOKTNE INDUCED MULTIMERIZATION OF SYNDECAN-4 IS MEDIATED BY GAG SIDE CHAINS
نویسندگان
چکیده
منابع مشابه
Transmembrane domain-induced oligomerization is crucial for the functions of syndecan-2 and syndecan-4.
The syndecans are known to form homologous oligomers that may be important for their functions. We have therefore determined the role of oligomerization of syndecan-2 and syndecan-4. A series of glutathione S-transferase-syndecan-2 and syndecan-4 chimeric proteins showed that all syndecan constructs containing the transmembrane domain formed SDS-resistant dimers, but not those lacking it. SDS-r...
متن کاملN-sulfation of heparan sulfate is critical for syndecan-4-mediated podocyte cell-matrix interactions.
Previous research has shown that podocytes unable to assemble heparan sulfate on cell surface proteoglycan core proteins have compromised cell-matrix interactions. This report further explores the role of N-sulfation of intact heparan chains in podocyte-matrix interactions. For the purposes of this study, a murine model in which the enzyme N-deacetylase/N-sulfotransferase 1 (NDST1) was specific...
متن کاملAppl Bioinformatics 2005; 4 (4): 227-246
1 Department of Computer Science, University of Pittsburgh, Pittsburgh, Pennsylvania, USA 2 University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA 3 Clinical Proteomics Facility, University of Pittsburgh, Pittsburgh, Pennsylvania, USA 4 Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA 5 Department of Surgery, University...
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Osteopontin (OPN) is a T helper type 1 immunoregulatory cytokine that plays a critical role in various inflammatory disorders. OPN exerts proinflammatory reactions through interaction with integrin receptors. OPN function can be modulated by protease digestion. However, the molecular mechanisms that regulate OPN function in vivo have not been elucidated. There are two putative heparin-binding d...
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Expression of the cell surface proteoglycan syndecan-1 (Sdc1) is frequently induced in stromal fibroblasts of invasive breast carcinomas. We have recently identified a correlation between stromal Sdc1 expression and extracellular matrix (ECM) fiber alignment, both in vitro and in vivo. ECMs derived from Sdc1-positive human mammary fibroblasts (HMF) showed an aligned fiber architecture, which co...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2011
ISSN: 1063-4584
DOI: 10.1016/s1063-4584(11)60273-2